Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

被引:396
作者
Abbink, Peter [1 ]
Larocca, Rafael A. [1 ]
De La Barrera, Rafael A. [2 ]
Bricault, Christine A. [1 ]
Moseley, Edward T. [1 ]
Boyd, Michael [1 ]
Kirilova, Marinela [1 ]
Li, Zhenfeng [1 ]
Ng'ang'a, David [1 ]
Nanayakkara, Ovini [1 ]
Nityanandam, Ramya [1 ]
Mercado, Noe B. [1 ]
Borducchi, Erica N. [1 ]
Agarwal, Arshi [1 ]
Brinkman, Amanda L. [1 ]
Cabral, Crystal [1 ]
Chandrashekar, Abishek [1 ]
Giglio, Patricia B. [1 ]
Jetton, David [1 ]
Jimenez, Jessica [1 ]
Lee, Benjamin C. [1 ]
Mojta, Shanell [1 ]
Molloy, Katherine [1 ]
Shetty, Mayuri [1 ]
Neubauer, George H. [1 ]
Stephenson, Kathryn E. [1 ]
Peron, Jean Pierre S. [3 ]
Zanotto, Paolo M. de A. [3 ]
Misamore, Johnathan [4 ]
Finneyfrock, Brad [4 ]
Lewis, Mark G. [4 ]
Alter, Galit [5 ]
Modjarrad, Kayvon [2 ,6 ]
Jarman, Richard G. [2 ]
Eckels, Kenneth H. [2 ]
Michael, Nelson L. [2 ]
Thomas, Stephen J. [2 ]
Barouch, Dan H. [1 ,5 ]
机构
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA
[2] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA
[3] Univ Sao Paulo, BR-05508000 Sao Paulo, Brazil
[4] Bioqual, Rockville, MD 20852 USA
[5] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA
[6] Henry M Jackson Fdn, Bethesda, MD 20817 USA
基金
巴西圣保罗研究基金会; 美国国家卫生研究院;
关键词
INFECTION; ANTIBODIES; MICE;
D O I
10.1126/science.aah6157
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans.
引用
收藏
页码:1129 / 1132
页数:4
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