Osteoinduction: translating preclinical promise into clinical reality

被引:14
作者
Ferretti, Carlo [2 ,3 ]
Ripamonti, Ugo [4 ,5 ]
Tsiridis, Eleftherios [6 ,7 ,8 ]
Kerawala, Cyrus J. [1 ]
Mantalaris, Athanasios [9 ]
Heliotis, Manolis [10 ]
机构
[1] Royal Marsden Hosp, Head & Neck Unit, London SW3 6JJ, England
[2] Univ Witwatersrand, Chris Hani Baragwanath Hosp, Div Maxillofacial & Oral Surg, ZA-2193 Johannesburg, South Africa
[3] Univ Witwatersrand, MRC, Bone Res Lab, ZA-2193 Johannesburg, South Africa
[4] Univ Witwatersrand, Sch Med, Fac Hlth Sci, Sch Clin Med,MRC, ZA-2193 Johannesburg, South Africa
[5] Univ Witwatersrand, Sch Med, Fac Hlth Sci, Bone Res Unit,MRC, ZA-2193 Johannesburg, South Africa
[6] Leeds Teaching Hosp, Leeds, W Yorkshire, England
[7] Univ Leeds, Sch Med, Leeds LS2 9JT, W Yorkshire, England
[8] Leeds Gen Infirm, Acad Orthopaed Unit, Leeds LS1 3EX, W Yorkshire, England
[9] Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn, London SW7 2AZ, England
[10] North West London Hosp NHS Trust, Northwick Pk Hosp, Harrow HA1 3UJ, Middx, England
关键词
Osteoinduction; Bone morphogenic proteins; Transforming growth factor-beta; MORPHOGENETIC PROTEIN-2 RHBMP-2; HUMAN OSTEOGENIC PROTEIN-1; VASCULARIZED BONE-GRAFT; MANDIBULAR RECONSTRUCTION; DEFECTS; INDUCTION; TRANSPLANTATION; TRANSFORMATION; AUGMENTATION; GROWTH;
D O I
10.1016/j.bjoms.2009.08.043
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
This review, the second in a series of three editorials, focuses on the problems of translating basic scientific research on induction of bone into reliable clinical applications. (C) 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:536 / 539
页数:4
相关论文
共 20 条
[1]   De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation [J].
Boyne, PJ ;
Lilly, LC ;
Marx, RE ;
Moy, PK ;
Nevins, M ;
Spagnoli, DB ;
Triplett, RG .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2005, 63 (12) :1693-1707
[2]   Off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans [J].
Carter, Todd G. ;
Brar, Pardeep S. ;
Tolas, Andrew ;
Beirne, O. Ross .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 66 (07) :1417-1425
[3]   Human segmental mandibular defects treated with naturally derived bone morphogenetic proteins [J].
Ferretti, C ;
Ripamonti, U .
JOURNAL OF CRANIOFACIAL SURGERY, 2002, 13 (03) :434-444
[4]   Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest [J].
Heliotis, M ;
Lavery, KM ;
Ripamonti, U ;
Tsiridis, E ;
di Silvio, L .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2006, 35 (03) :265-269
[5]   Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2) [J].
Herford, Alan S. ;
Boyne, Philip J. .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 66 (04) :616-624
[6]  
JOHNSON EE, 1988, CLIN ORTHOP RELAT R, P257
[7]   TISSUE TRANSFORMATION INTO BONE INVIVO - A POTENTIAL PRACTICAL APPLICATION [J].
KHOURI, RK ;
KOUDSI, B ;
REDDI, H .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (14) :1953-1955
[8]   Successful mandibular reconstruction using a BMP bioimplant [J].
Moghadam, HG ;
Urist, MR ;
Sandor, GKB ;
Clokie, CML .
JOURNAL OF CRANIOFACIAL SURGERY, 2001, 12 (02) :119-127
[9]   RECONSTRUCTION OF THE BONE-BONE MARROW ORGAN BY OSTEOGENIN, A BONE MORPHOGENETIC PROTEIN, AND DEMINERALIZED BONE-MATRIX IN CALVARIAL DEFECTS OF ADULT PRIMATES [J].
RIPAMONTI, U ;
MA, SS ;
CUNNINGHAM, NS ;
YEATES, L ;
REDDI, AH .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1993, 91 (01) :27-36
[10]   Recombinant transforming growth factor-beta 1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation [J].
Ripamonti, U ;
Duneas, N ;
VandenHeever, B ;
Bosch, C ;
Crooks, J .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (10) :1584-1595