Quantitative structure-activity relationship study on sulfanilamide Schiff's bases: Carbonic Anhydrase (CA) inhibitors

被引：22

作者：

Agrawal, VK

Srivastava, S

Khadikar, PV ^{[1
]}

Supuran, CT

机构：

[1] APS Univ, QSAR, Rewa 486003, India

[2] APS Univ, Comp Chem Labs, Rewa 486003, India

[3] Laxmi Fumigat & Pest Control Pvt Ltd, Div Res, Indore 452007, India

[4] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Sesto Fiorentino, Firenze, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 24期

关键词：

D O I：

10.1016/j.bmc.2003.09.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paper deals with quantitative structure-activity studies on a group of sulfanilamide Schiffs base inhibitors of carbonic anhydrase (CA) using distance-based topological indices. The regression analysis of the data has shown that the activities of the compounds used in inhibiting Carbonic AnhydraseII (CAII) activity can be modeled excellently in multi-parametric model in that some indicator parameters are also involved. The results are discussed critically. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：5353 / 5362

页数：10

共 24 条

[1] Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy [J].