In vitro resistance to thrombin-induced platelet microbicidal protein is associated with enhanced progression and hematogenous dissemination in experimental Staphylococcus aureus infective endocarditis

被引：42

作者：

Dhawan, VK

Bayer, AS

Yeaman, MR

机构：

[1] Univ Calif Los Angeles, King Drew Med Ctr, Los Angeles, CA 90059 USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[3] Harbor UCLA Med Ctr, St Johns Cardiovasc Res Ctr, Torrance, CA 90502 USA

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 07期

关键词：

D O I：

10.1128/IAI.66.7.3476-3479.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the influence Of thrombin-induced platelet microbicidal protein 1 (tPMP-1) on the progression and hematogenous dissemination of experimental endocarditis caused by isogenic Staphylococus aureus strains differing in tPMP susceptibility (tPMP(S)) or resistance (tPMP(r)) in vitro. Following simultaneous challenge of animals with both strains, significantly higher tPMP(r) bacterial densities were present in vegetations (P < 0.0001), kidneys (P < 0.0001), and spleens (P < 0.0001) compared with those for the tPMPS strain. These data indicate that tPMP-1 limits the intravegetation proliferation and hematogenous dissemination of a tPMP(S) strain in experimental endocarditis, while the tPMP(r) phenotype confers a selective advantage associated with the enhanced progression of this infection.

引用

页码：3476 / 3479

页数：4

共 25 条

[11] DURACK DT, 1972, BRIT J EXP PATHOL, V53, P44
[12] THE PLATELET INTERACTIVITY PHENOTYPE OF STREPTOCOCCUS-SANGUIS INFLUENCES THE COURSE OF EXPERIMENTAL ENDOCARDITIS
HERZBERG, MC
MACFARLANE, GD
GONG, KE
ARMSTRONG, NN
WITT, AR
ERICKSON, PR
MEYER, MW
[J]. INFECTION AND IMMUNITY, 1992, 60 (11) : 4809 - 4818
[13] HERZBERG MC, 1990, INFECT IMMUN, V58, P512
[14] Staphylocidal action of thrombin-induced platelet microbicidal protein is influenced by microenvironment and target cell growth phase
Koo, SP
Yeaman, MR
Bayer, AS
[J]. INFECTION AND IMMUNITY, 1996, 64 (09) : 3758 - 3764
[15] PERLMAN BB, 1971, YALE J BIOL MED, V42, P394
[16] NOSOCOMIAL BLOOD-STREAM INFECTIONS - SECULAR TRENDS IN RATES, MORTALITY, AND CONTRIBUTION TO TOTAL HOSPITAL DEATHS
PITTET, D
WENZEL, RP
[J]. ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (11) : 1177 - 1184
[17] SAHL HG, 1981, J GEN MICROBIOL, V127, P377
[18] EFFECT OF THROMBOCYTOPENIA ON THE EARLY COURSE OF STREPTOCOCCAL ENDOCARDITIS
SULLAM, PM
FRANK, U
YEAMAN, MR
TAUBER, MG
BAYER, AS
CHAMBERS, HF
[J]. JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (04) : 910 - 914
[19] IN-VITRO RESISTANCE TO PLATELET MICROBICIDAL PROTEIN CORRELATES WITH ENDOCARDITIS SOURCE AMONG BACTEREMIC STAPHYLOCOCCAL AND STREPTOCOCCAL ISOLATES
WU, T
YEAMAN, MR
BAYER, AS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (04) : 729 - 732
[20] THROMBIN-INDUCED RABBIT PLATELET MICROBICIDAL PROTEIN IS FUNGICIDAL INVITRO
YEAMAN, MR
IBRAHIM, AS
EDWARDS, JE
BAYER, AS
GHANNOUM, MA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (03) : 546 - 553

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