The role of neuronal signaling in controlling cerebral blood flow

被引：122

作者：

Drake, Carrie T. ^{[1
]}

Iadecola, Costantino ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10128 USA

来源：

BRAIN AND LANGUAGE | 2007年 / 102卷 / 02期

关键词：

functional hyperemia; cerebral blood flow; neurovascular unit; BOLD;

D O I：

10.1016/j.bandl.2006.08.002

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI). (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：141 / 152

页数：12

共 132 条

[1]

Abeles M., 1991, Corticonics: Neural circuits of the cerebral cortex, DOI DOI 10.1017/CBO9780511574566

[2]

ACKERMANN RF, 1984, J NEUROSCI, V4, P251

[3] IMPORTANCE OF NITRIC-OXIDE FOR LOCAL INCREASES OF BLOOD-FLOW IN RAT CEREBELLAR CORTEX DURING ELECTRICAL-STIMULATION [J].

AKGOREN, N ;

FABRICIUS, M ;

LAURITZEN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5903-5907

[4] Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats [J].

Alkayed, NJ ;

Birks, EK ;

Narayanan, J ;

Petrie, KA ;

KohlerCabot, AE ;

Harder, DR .

STROKE, 1997, 28 (05) :1066-1072

[5] CNS energy metabolism as related to function [J].

Ames, A .

BRAIN RESEARCH REVIEWS, 2000, 34 (1-2) :42-68

[6]

ARNERIC SP, 1989, INT CONGR SER, V869, P381

[7] NEURONAL AND ENDOTHELIAL SITES OF ACETYLCHOLINE SYNTHESIS AND RELEASE ASSOCIATED WITH MICROVESSELS IN RAT CEREBRAL-CORTEX - ULTRASTRUCTURAL AND NEUROCHEMICAL STUDIES [J].

ARNERIC, SP ;

HONIG, MA ;

MILNER, TA ;

GRECO, S ;

IADECOLA, C ;

REIS, DJ .

BRAIN RESEARCH, 1988, 454 (1-2) :11-30

[8] An energy budget for signaling in the grey matter of the brain [J].

Attwell, D ;

Laughlin, SB .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (10) :1133-1145

[9] Lactate is a preferential oxidative energy substrate over glucose for neurons in culture [J].

Bouzier-Sore, AK ;

Voisin, P ;

Canioni, P ;

Magistretti, TJ ;

Pellerin, T .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1298-1306

[10]

Braitenberg V., 1998, CORTEX STAT GEOMETRY, DOI [DOI 10.1007/978-3-662-03733-1_27, 10.1007/978-3-662-03733-1]

← 1 2 3 4 5 6 7 8 9 10 →