The role of neuronal signaling in controlling cerebral blood flow

被引：122

作者：

Drake, Carrie T. ^{[1
]}

Iadecola, Costantino ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10128 USA

来源：

BRAIN AND LANGUAGE | 2007年 / 102卷 / 02期

关键词：

functional hyperemia; cerebral blood flow; neurovascular unit; BOLD;

D O I：

10.1016/j.bandl.2006.08.002

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI). (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：141 / 152

页数：12

共 132 条

[61] Relationship of spikes, synaptic activity, and local changes of cerebral blood flow [J].

Lauritzen, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (12) :1367-1383

[62] NITRIC-OXIDE AND ADENOSINE MEDIATE VASODILATION DURING FUNCTIONAL ACTIVATION IN CEREBELLAR CORTEX [J].

LI, J ;

IADECOLA, C .

NEUROPHARMACOLOGY, 1994, 33 (11) :1453-1461

[63]

Lindauer U, 1999, AM J PHYSIOL-HEART C, V277, pH799, DOI 10.1152/ajpheart.1999.277.2.H799

[64] Mechanisms, challenges and opportunities in stroke [J].

Lo, EH ;

Dalkara, T ;

Moskowitz, MA .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (05) :399-415

[65] Neurophysiological investigation of the basis of the fMRI signal [J].

Logothetis, NK ;

Pauls, J ;

Augath, M ;

Trinath, T ;

Oeltermann, A .

NATURE, 2001, 412 (6843) :150-157

[66] Interpreting the BOLD signal [J].

Logothetis, NK ;

Wandell, BA .

ANNUAL REVIEW OF PHYSIOLOGY, 2004, 66 :735-769

[67] MR imaging in the non-human primate: studies of function and of dynamic connectivity [J].

Logothetis, NK .

CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (05) :630-642

[68]

LONG JB, 1992, J PHARMACOL EXP THER, V260, P1425

[69] Neurovascular relationships in hippocampal slices: Physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels [J].

Lovick, TA ;

Brown, LA ;

Key, BJ .

NEUROSCIENCE, 1999, 92 (01) :47-60

[70] Integrin signaling, free radicals, and tyrosine kinase mediate flow constriction in isolated cerebral arteries [J].

Madden, JA ;

Christman, NJT .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (06) :H2264-H2271

← 2 3 4 5 6 7 8 9 10 11 →