A20, an inhibitor of cell death, self-associates by its zinc finger domain

被引：42

作者：

DeValck, D

Heyninck, K

VanCriekinge, W

Contreras, R

Beyaert, R

Fiers, W

机构：

[1] STATE UNIV GHENT,MOLEC BIOL LAB,B-9000 GHENT,BELGIUM

[2] FLANDERS INTERUNIV INST BIOTECHNOL,B-9000 GHENT,BELGIUM

来源：

FEBS LETTERS | 1996年 / 384卷 / 01期

关键词：

zinc finger protein; protein-protein interaction; self-association; apoptosis; necrosis; tumor necrosis factor;

D O I：

10.1016/0014-5793(96)00283-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells, The A20 protein belongs to a novel class of Cys(2)/Cys(2) zinc finger proteins, and has been characterized as an inhibitor of both apoptotic and necrotic cell death. In order to clarify its molecular mechanism of action, we used the yeast-based two-hybrid system to screen for A20-associated proteins, Here we report that A20 is able to self-associate, and demonstrate that the latter interaction is mediated by its zinc finger domain.

引用

页码：61 / 64

页数：4