共 44 条
Hemostatic Disorders in Type 1 Diabetes Mellitus
被引:34
作者:
Targher, Giovanni
[1
]
Chonchol, Michel
[2
]
Zoppini, Giacomo
[1
]
Franchini, Massimo
[3
]
机构:
[1] Univ Verona, Dept Med, Endocrinol Sect, I-37126 Verona, Italy
[2] Univ Colorado, Denver Hlth Sci Ctr, Div Renal Dis & Hypertens, Aurora, CO USA
[3] Univ Hosp Parma, Immunohematol & Transfus Ctr, Dept Pathol & Lab Med, Parma, Italy
关键词:
Type;
1;
diabetes;
coagulation;
fibrinolysis;
hemostatic disorders;
ACTIVATABLE FIBRINOLYSIS INHIBITOR;
SOLUBLE CD40 LIGAND;
ENDOTHELIAL DYSFUNCTION;
MICROVASCULAR COMPLICATIONS;
ADHESION MOLECULES;
MARKERS;
INFLAMMATION;
ASSOCIATION;
NEPHROPATHY;
COAGULATION;
D O I:
10.1055/s-0030-1270072
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
This review summarizes current knowledge of the adverse effects of type 1 diabetes mellitus on coagulation and fibrinolysis. Although further larger studies are needed to provide more definitive information, patients with type 1 diabetes exhibit a proinflammatory/procoagulant condition deriving from increased platelet adhesiveness, activation of the coagulation system, and decreased plasma fibrinolytic potential. This review also focuses on recent data from large prospective studies suggesting a strong association between procoagulant imbalance and development of chronic vascular complications in people with type 1 diabetes. It is likely that a greater appreciation of the intimate interactions between endothelial integrity, coagulation and fibrinolytic factors, and platelets in type 1 diabetes will provide a greater understanding of the risk of developing cardiovascular disease and microvascular complications such as nephropathy and retinopathy in this patient population.
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页码:58 / 65
页数:8
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