Molecular genetics of familial renal cell carcinoma syndromes

被引：35

作者：

Cohen, D ^{[1
]}

Zhou, M ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Cleveland, OH 44195 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2005年 / 25卷 / 02期

关键词：

D O I：

10.1016/j.cll.2005.01.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Renal cell carcinoma (RCC) represents a group of clinically and genetically diverse diseases. Familial RCC syndromes, although rare, provide an invaluable model to study the molecular mechanisms of renal carcinogenesis. Many oncogenes, and tumor suppressor genes have been identified as responsible for several forms of familial RCC syndromes. Understanding of the molecular pathways of these genes will have significant impact on the diagnosis and treatment of familial and sporadic RCCs.

引用

页码：259 / +

页数：20

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