A cationic zinc porphyrin as a chiroptical probe for Z-DNA

被引：116

作者：

Balaz, M

De Napoli, M

Holmes, AE

Mammana, A

Nakanishi, K

Berova, N

Purrello, R

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 26期

关键词：

chirality; circular dichroism; DNA; porphyrinoids; sensors;

D O I：

10.1002/anie.200501149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Z for zinc and Z-DNA: As a result of different binding modes, a cationic zinc porphyrin discriminates between B and Z conformations of DNA and holds promise as a probe for Z-DNA. A very intense induced circular dichroism (ICD) effect with a bisignate spectrum is observed upon interaction of the porphyrin with Z-DNA (see graphic; porphyrin red, Z-DNA green), whereas only a weak ICD spectrum results upon its interaction with B-DNA (Figure Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：4006 / 4009

页数：4

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