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Diagnosis and treatment of antibody-mediated kidney allograft rejection

被引：47
作者：
Böhmig, G
Regele, H
机构：
[1] Univ Vienna, AKH, Clin Inst Pathol, A-1090 Vienna, Austria
[2] Univ Vienna, Dept Internal Med 3, Div Nephrol & Dialysis, Vienna, Austria
来源：
TRANSPLANT INTERNATIONAL | 2003年 / 16卷 / 11期
关键词：
antibody-mediated rejection; apheresis; C4d; immunoadsorption; kidney; transplantation;
D O I：
10.1111/j.1432-2277.2003.tb00241.x
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Evidence of a significant pathogenetic role of donor-reactive antibodies (DRA) in kidney allograft rejection is accumulating. At least, partially owing to the recent discovery of the complement split product C4d as a valuable rejection marker, antibody-mediated rejection (AMR) has regained increasing attention. We review here the value of various diagnostic criteria, including immunohistochemistry (C4d staining), histomorphology and posttransplant serology, for the diagnosis of AMR. Furthermore, the mechanisms underlying alloantibody/complement-mediated allograft injury are discussed in detail. Finally, a thorough discussion of recently proposed "anti-humoral" therapeutic strategies is provided.
引用
收藏
页码：773 / 787
页数：15
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