Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the mediterranean ascidian Aplidium conicum

被引：19

作者：

Aiello, A

Esposito, G

Fattorusso, E

Iuvone, T

Luciano, P

Menna, M

机构：

[1] Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

来源：

STEROIDS | 2003年 / 68卷 / 09期

关键词：

9,11-secosterols; ascidians; tunicates; Aplidium conicum; NMR; cytotoxic agents;

D O I：

10.1016/S0039-128X(03)00098-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two novel 9,11-secosterols, aplidiasterols A (3beta,6beta,11-trihydroxy-9,11-seco-5alpha-cholest-7-en-9-one, 1) and B (3beta,5alpha,6beta,11-tetra-hydroxy-9,11-secocholest-7-en-9-one, 2), along with the known secosterols 3 and 4, were isolated from the Mediterranean ascidian Aplidium conicum and their structures were determined by spectroscopic data. Aplidiasterols A and B were found to be cytotoxic against rat glioma (C6) and murine monocyte/macrophage (J774) tumor cells in vitro. Compounds 1-4 represent the first example of secosterols isolated from tunicates. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：719 / 723

页数：5

共 21 条

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