RNAi as a bioinformatics consumer

被引：11

作者：

Sachidanandam, R ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

BRIEFINGS IN BIOINFORMATICS | 2005年 / 6卷 / 02期

关键词：

RNAi; miRNA; PTGS; TGS; gene silencing; chromatin;

D O I：

10.1093/bib/6.2.146

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

RNAi has shown great potential for use as a tool for biological discovery, analysis and therapeutics. The involvement of the RNAi pathway in post-transcription silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics throws up several bioinformatics challenges. This paper delineates several areas of research and reviews work that has already been done, the tools that are available and the challenges that lie ahead.

引用

页码：146 / 162

页数：17

共 108 条

[11] HIV-1 encoded candidate micro-RNAs and their cellular targets [J].

Bennasser Y. ;

Le S.-Y. ;

Yeung M.L. ;

Jeang K.-T. .

Retrovirology, 1 (1)

[12] A large-scale RNAi screen in human cells identifies new components of the p53 pathway [J].

Berns, K ;

Hijmans, EM ;

Mullenders, J ;

Brummelkamp, TR ;

Velds, A ;

Heimerikx, M ;

Kerkhoven, RM ;

Madiredjo, M ;

Nijkamp, W ;

Weigelt, B ;

Agami, R ;

Ge, W ;

Cavet, G ;

Linsley, PS ;

Beijersbergen, RL ;

Bernards, R .

NATURE, 2004, 428 (6981) :431-437

[13] DNA METHYLATION - EVOLUTION OF A BACTERIAL IMMUNE FUNCTION INTO A REGULATOR OF GENE-EXPRESSION AND GENOME STRUCTURE IN HIGHER EUKARYOTES [J].

BESTOR, TH .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1990, 326 (1235) :179-187

[14] DNA methylation patterns and epigenetic memory [J].

Bird, A .

GENES & DEVELOPMENT, 2002, 16 (01) :6-21

[15] GENE NUMBER, NOISE-REDUCTION AND BIOLOGICAL COMPLEXITY [J].

BIRD, AP .

TRENDS IN GENETICS, 1995, 11 (03) :94-100

[16] Detection of 91 potential in plant conserved plant microRNAs in Arabidopsis thaliana and Oryza sativa identifies important target genes [J].

Bonnet, E ;

Wuyts, J ;

Rouzé, P ;

Van de Peer, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (31) :11511-11516

[17] Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences [J].

Bonnet, E ;

Wuyts, J ;

Rouzé, P ;

Van de Peer, Y .

BIOINFORMATICS, 2004, 20 (17) :2911-2917

[18] Human Epigenome Project - Up and running [J].

Bradbury, J .

PLOS BIOLOGY, 2003, 1 (03) :316-319

[19] The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis [J].

Carmell, MA ;

Xuan, ZY ;

Zhang, MQ ;

Hannon, GJ .

GENES & DEVELOPMENT, 2002, 16 (21) :2733-2742

[20]

Colot V, 1999, BIOESSAYS, V21, P402, DOI 10.1002/(SICI)1521-1878(199905)21:5<402::AID-BIES7>3.0.CO

← 1 2 3 4 5 6 7 8 9 10 →