Synthesis and Biosynthetic Trafficking of Membrane Lipids

被引：81

作者：

Blom, Tomas ^{[1
]}

Somerharju, Pentti ^{[2
]}

Ikonen, Elina ^{[1
]}

机构：

[1] Univ Helsinki, Dept Anat, Inst Biomed, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Dept Med Biochem & Dev Biol, Inst Biomed, FIN-00014 Helsinki, Finland

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2011年 / 3卷 / 08期

基金：

芬兰科学院;

关键词：

ACUTE REGULATORY PROTEIN; SPHINGOLIPID ACTIVATOR PROTEINS; ENDOPLASMIC-RETICULUM; PLASMA-MEMBRANE; PHOSPHATIDYLSERINE DECARBOXYLASE; GLYCOSPHINGOLIPID SYNTHESIS; NONVESICULAR TRAFFICKING; SACCHAROMYCES-CEREVISIAE; INTRACELLULAR-TRANSPORT; CHOLESTEROL-METABOLISM;

D O I：

10.1101/cshperspect.a004713

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Eukaryotic cells can synthesize thousands of different lipid molecules that are incorporated into their membranes. This involves the activity of hundreds of enzymes with the task of creating lipid diversity. In addition, there are several, typically redundant, mechanisms to transport lipids from their site of synthesis to other cellular membranes. Biosynthetic lipid transport helps to ensure that each cellular compartment will have its characteristic lipid composition that supports the functions of the associated proteins. In this article, we provide an overview of the biosynthesis of the major lipid constituents of cell membranes, that is, glycerophospholipids, sphingolipids, and sterols, and discuss the mechanisms by which these newly synthesized lipids are delivered to their target membranes.

引用

页码：1 / 16

页数：16

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