Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

被引:551
作者
Xiong, YM
Miyamoto, N
Shibata, K
Valasek, MA
Motoike, T
Kedzierski, RM
Yanagisawa, M
机构
[1] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA
[3] Japan Sci & Technol Agcy, Explorat Res Adv Technol, Yanagisawa Orphan Receptor Project, Tokyo 1350064, Japan
关键词
D O I
10.1073/pnas.2637002100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.
引用
收藏
页码:1045 / 1050
页数:6
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