Chiral synthetic block based on (R)-pantolactone

被引：5

作者：

Akbutina, FA ^{[1
]}

Sadretdinov, IF ^{[1
]}

Selezneva, NK ^{[1
]}

Miftakhov, MS ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

来源：

MENDELEEV COMMUNICATIONS | 2003年 / 03期

关键词：

D O I：

10.1070/MC2003v013n03A13EH001755

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of (R)-(+)-2,2-dimethyl-4-(1,1-dimethyl-2-oxo-1-butyl)-1,3-dioxolane from (R)-pantolactone has been developed.

引用

页码：151 / 152

页数：2

共 18 条

[1] Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity
Altmann, KH
Wartmann, M
O'Reilly, T
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2000, 1470 (03): : M79 - M91
[2] Synthesis and biological evaluation of highly potent analogues of epothilones B and D
Altmann, KH
Bold, G
Caravatti, G
Flörsheimer, A
Guagnano, V
Wartmann, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (24) : 2765 - 2768
[3] Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel
Chou, TC
Zhang, XG
Harris, CR
Kuduk, SD
Balog, A
Savin, KA
Bertino, JR
Danishefsky, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15798 - 15802
[4] Epothilons A and B: Antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria) - Production, physico-chemical and biological properties
Gerth, K
Bedorf, N
Hofle, G
Irschik, H
Reichenbach, H
[J]. JOURNAL OF ANTIBIOTICS, 1996, 49 (06) : 560 - 563
[5] The synthesis and evaluation of 12,13-benzodesoxyepothilone B: a highly convergent route
Glunz, PW
He, LF
Horwitz, SB
Chakravarty, S
Ojima, I
Chou, TC
Danishefsky, SJ
[J]. TETRAHEDRON LETTERS, 1999, 40 (38) : 6895 - 6898
[6] Dianion equivalents corresponding to the polypropionate domain of epothilone B
Harris, CR
Kuduk, SD
Savin, K
Balog, A
Danishefsky, SJ
[J]. TETRAHEDRON LETTERS, 1999, 40 (12) : 2263 - 2266
[7] Epothilone A and B - Novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution
Hofle, GH
Bedorf, N
Steinmetz, H
Schomburg, D
Gerth, K
Reichenbach, H
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (13-14): : 1567 - 1569
[8] Insights into long-range structural effects on the stereochemistry of aldol condensations: A practical total synthesis of desoxyepothilone F
Lee, CB
Wu, ZC
Zhang, F
Chappell, MD
Stachel, SJ
Chou, TC
Guan, YB
Danishefsky, SJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (22) : 5249 - 5259
[9] Nicolaou KC, 1998, ANGEW CHEM INT EDIT, V37, P84, DOI 10.1002/(SICI)1521-3773(19980202)37:1/2<84::AID-ANIE84>3.0.CO
[10] 2-V

← 1 2 →