DNA damage: Chk1 and Cdc25, more than meets the eye

被引：51

作者：

Walworth, NC ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pharmacol, Piscataway, NJ 08854 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(00)00160-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Control of mitotic entry is a component of the checkpoint response that contributes to cell survival following DNA damage. In some eukaryotic cells, mitotic entry relies heavily on regulation of the state of tyrosine phosphorylation of the cyclin-dependent kinase Cdc2. Evidence that checkpoint regulation of cell-cycle progression operates through controlling the state of Cdc2 tyrosine phosphorylation exists. Whether other targets of the checkpoint pathway could play important roles in the response to DNA damage is a subject of ongoing investigations.

引用

页码：78 / 82

页数：5

共 48 条

[41] Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms [J].