All-DNA finite-state automata with finite memory

被引：103

作者：

Wang, Zhen-Gang ^{[1
]}

Elbaz, Johann ^{[1
]}

Remacle, F. ^{[2
]}

Levine, R. D. ^{[1
,3
,4
]}

Willner, Itamar ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

[2] Univ Liege, Dept Chem, B-4000 Liege, Belgium

[3] Univ Calif Los Angeles, Dept Chem & Biochem, Crump Inst Mol Imaging, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 51期

基金：

以色列科学基金会;

关键词：

biocomputing; DNA machines; sensor; chemical recognition; chemical input; TWEEZERS; MACHINE;

D O I：

10.1073/pnas.1015858107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Biomolecular logic devices can be applied for sensing and nanomedicine. We built three DNA tweezers that are activated by the inputs H+/OH-; Hg2+/cysteine; nucleic acid linker/complementary antilinker to yield a 16-states finite-state automaton. The outputs of the automata are the configuration of the respective tweezers (opened or closed) determined by observing fluorescence from a fluorophore/quencher pair at the end of the arms of the tweezers. The system exhibits a memory because each current state and output depend not only on the source configuration but also on past states and inputs.

引用

页码：21996 / 22001

页数：6

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