Guaroa Virus Infection among Humans in Bolivia and Peru

被引:18
作者
Aguilar, Patricia V. [1 ]
Morrison, Amy C. [4 ,5 ]
Rocha, Claudio [4 ]
Watts, Douglas M. [2 ,3 ]
Beingolea, Luis [7 ]
Suarez, Victor [8 ]
Vargas, Jorge [9 ]
Cruz, Cristhopher [6 ]
Guevara, Carolina [6 ]
Montgomery, Joel M. [6 ]
Tesh, Robert B.
Kochel, Tadeusz J. [6 ]
机构
[1] USN, Med Res Ctr Detachment, Washington, DC 20521 USA
[2] Univ Texas El Paso, Res Off, El Paso, TX 79968 USA
[3] Univ Texas El Paso, Sponsored Projects, El Paso, TX 79968 USA
[4] Naval Med Res Ctr Detachment, Iquitos, Peru
[5] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA
[6] Naval Med Res Ctr Detachment, Lima, Peru
[7] Off Epidemiol, Lima, Peru
[8] NIH, Lima, Peru
[9] Ctr Enfermedades Trop, Santa Cruz, CA, Bolivia
基金
美国国家卫生研究院;
关键词
VENEZUELAN-EQUINE-ENCEPHALITIS; ARTHROPOD-BORNE VIRUSES; AMAZON BASIN REGION; VIRAL-RNA SEGMENT; GENETIC-ANALYSIS; BUNYAVIRUSES; TRANSMISSION; CULICIDAE; DIPTERA; COMPLEX;
D O I
10.4269/ajtmh.2010.10-0116
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Guaroa virus (GROV) was first isolated from humans in Colombia in 1959. Subsequent isolates of the virus have been recovered from febrile patients and mosquitoes in Brazil. Colombia. and Panama, however, association of the virus with human disease has been unclear As part of a study on the etiology of febrile illnesses in Peru and Bolivia, 14 GROV strains were isolated from patients with febrile illnesses, and 3 additional cases were confirmed by IgM serocon-version The prevalence rate of GROV antibodies among Iquitos residents was 13%. the highest rates were among persons with occupations such as woodcutters, fisherman, and oil-field workers Genetic characterization of representative GROV isolates indicated that strains from Peru and Bolivia form a monophyletic group that can be distinguished from strains isolated earlier in Brazil and Colombia. This study confirms GROV as a cause of febrile illness in tropical regions of Central and South America
引用
收藏
页码:714 / 721
页数:8
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