Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats

被引：2

作者：

Henninger, Nils ^{[1
]}

Wang, Qi ^{[2
]}

Okun, Jurgen G. ^{[3
]}

Schwab, Stefan ^{[2
,4
]}

Krause, Martin

机构：

[1] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

[2] Univ Heidelberg, Dept Neurol, D-69120 Heidelberg, Germany

[3] Univ Heidelberg, Dept Gen Pediat, D-69120 Heidelberg, Germany

[4] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 08期

关键词：

COMT-inhibitor; folate; homocysteine; levodopa; movement disorder; nitrous oxide;

D O I：

10.1016/j.parkreldis.2006.11.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: This study investigated whether brief exposure to nitrous oxide (N2O) exacerbates levodopa-induced hyperhomocysteinemia, and if co-treatment with folate or entacapone could reduce total plasma homocysteine (tHcy) levels. Methods: Male Wistar rats (n = 9 per group) were randomly treated with vehicle/N2O (group 1), levodopa/nitrogen (group 2), levodopa/N2O (group 3), levodopa/N2O + folate (group 4), or levodopa/N2O + entacapone (group 5). tHcy was measured at 12 min, 4, 8, and 12 h after anesthesia. Results and conclusion: The combination of N2O-exposure and levodopa treatment significantly increased tHcy in rats. This hyperhomocysteinemia, could be prevented by entacapone but not folate co-administration. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：524 / 527

页数：4

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