A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression

被引：79

作者：

Nishioka, Y ^{[1
]}

Sagae, S ^{[1
]}

Nishikawa, A ^{[1
]}

Ishioka, S ^{[1
]}

Kudo, R ^{[1
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Obstet & Gynecol, Chuo Ku, Sapporo, Hokkaido 0600061, Japan

来源：

CANCER LETTERS | 2003年 / 200卷 / 01期

关键词：

Matrix metalloproteinase-1; single nucleotide polymorphism; cervical cancer;

D O I：

10.1016/S0304-3835(03)00411-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at - 1607 bp) creates Ets binding sites, and correlations between this SNP and cancer susceptibility have been reported for various cancers. In this study, we genotyped the SNP in 23 cervical intraepithelial neoplasias (CIN) and 86 cervical cancer specimens. We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：49 / 55

页数：7

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