Identification of aminopiperidine benzamides as WCHr1 antagonists

被引：19

作者：

Vasudevan, A ^{[1
]}

Verzal, MK

Wodka, D

Souers, AJ

Blackburn, C

Che, JL

Lai, SJ

Brodjian, S

Falls, DH

Dayton, BD

Govek, E

Daniels, T

Geddes, B

Marsh, KC

Hernandez, LE

Collins, CA

Kym, PR

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Metab Dis Res, Abbott Pk, IL 60064 USA

[2] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

melanin concentrating hormone; benzamides; obesity;

D O I：

10.1016/j.bmcl.2005.05.023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The identification of a novel series of benzamide-containing MCHr1 antagonists is described. Compound 22 displayed moderate efficacy in a diet induced obesity mice model. (c) 2005 Published by Elsevier Ltd.

引用

页码：3412 / 3416

页数：5

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