Melanin-concentrating hormone receptor: An orphan receptor fits the key

被引：85

作者：

Saito, Y ^{[1
]}

Nothacker, HP

Civelli, O

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Mol Biol, Tokyo, Japan

[2] Univ Calif Irvine, Dept Dev & Cell Biol, Dept Pharmacol, Irvine, CA 92697 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 08期

关键词：

D O I：

10.1016/S1043-2760(00)00290-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The melanin-concentrating hormone (MCH), a hypothalamic peptide, tvas identified initially in teleost fish as a regulator of pigmentary changes in background adaptation, and was litter also found, in mammals, to be a regulator of feeding and energy homeostasis. Its specific receptor remained an enigma until very recently when it was identified as the orphan G-protein-coupled receptor SLC-1. This review focuses on the identification, structure and signaling of the MCH receptor and discusses some of the implications of its discovery.

引用

页码：299 / 303

页数：7

共 34 条

[1] Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1) [J].

Bächner, D ;

Kreienkamp, HJ ;

Weise, C ;

Buck, F ;

Richter, D .

FEBS LETTERS, 1999, 457 (03) :522-524

[2]

BAKER BI, 1991, INT REV CYTOL, V126, P1

[3] THE MELANIN-CONCENTRATING HORMONE SYSTEM OF THE RAT-BRAIN - AN IMMUNIZATION AND HYBRIDIZATION HISTOCHEMICAL CHARACTERIZATION [J].

BITTENCOURT, JC ;

PRESSE, F ;

ARIAS, C ;

PETO, C ;

VAUGHAN, J ;

NAHON, JL ;

VALE, W ;

SAWCHENKO, PE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 319 (02) :218-245

[4] NEUROPEPTIDE-E-I ANTAGONIZES THE ACTION OF MELANIN-CONCENTRATING HORMONE ON STRESS-INDUCED RELEASE OF ADRENOCORTICOTROPIN IN THE RAT [J].

BLUETPAJOT, MT ;

PRESSE, F ;

VOKO, Z ;

HOEGER, C ;

MOUNIER, F ;

EPELBAUM, J ;

NAHON, JL .

JOURNAL OF NEUROENDOCRINOLOGY, 1995, 7 (04) :297-303

[5]

BUNZOW JR, 1992, METHODS NEUROSCIENCE, P441

[6] Melanin-concentrating hormone binding sites in human SVK14 keratinocytes [J].

Burgaud, JL ;

Poosti, R ;

Fehrentz, JA ;

Martinez, J ;

Nahon, JL .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (03) :622-629

[7] Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1 [J].

Chambers, J ;

Ames, RS ;

Bergsma, D ;

Muir, A ;

Fitzgerald, LR ;

Hervieu, G ;

Dytko, GM ;

Foley, JJ ;

Martin, J ;

Liu, WS ;

Park, J ;

Ellis, C ;

Ganguly, S ;

Konchar, S ;

Cluderay, J ;

Leslie, R ;

Wilson, S ;

Sarau, HM .

NATURE, 1999, 400 (6741) :261-265

[8] Functional genomics, the search for novel neurotransmitters and neuropeptides [J].

Civelli, O .

FEBS LETTERS, 1998, 430 (1-2) :55-58

[9] MELANIN-CONCENTRATING HORMONE-BINDING TO MOUSE MELANOMA-CELLS IN-VITRO [J].

DROZDZ, R ;

SIEGRIST, W ;

BAKER, BI ;

CHLUBADETAPIA, J ;

EBERLE, AN .

FEBS LETTERS, 1995, 359 (2-3) :199-202

[10] Behavioral effects of alpha-MSH and MCH after central administration in the female rat [J].

Gonzalez, MI ;

Vaziri, S ;

Wilson, CA .

PEPTIDES, 1996, 17 (01) :171-177

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