Melanin-concentrating hormone receptor: An orphan receptor fits the key

被引：85

作者：

Saito, Y ^{[1
]}

Nothacker, HP

Civelli, O

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Mol Biol, Tokyo, Japan

[2] Univ Calif Irvine, Dept Dev & Cell Biol, Dept Pharmacol, Irvine, CA 92697 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 08期

关键词：

D O I：

10.1016/S1043-2760(00)00290-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The melanin-concentrating hormone (MCH), a hypothalamic peptide, tvas identified initially in teleost fish as a regulator of pigmentary changes in background adaptation, and was litter also found, in mammals, to be a regulator of feeding and energy homeostasis. Its specific receptor remained an enigma until very recently when it was identified as the orphan G-protein-coupled receptor SLC-1. This review focuses on the identification, structure and signaling of the MCH receptor and discusses some of the implications of its discovery.

引用

页码：299 / 303

页数：7

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