Insecticidal and antifungal activities of aminorhodanine derivatives

被引：23

作者：

Inamori, Y ^{[1
]}

Okamoto, Y

Takegawa, Y

Tsujibo, H

Sakagami, Y

Kumeda, Y

Shibata, M

Numata, A

机构：

[1] Osaka Univ Pharmaceut Sci, Osaka 5690000, Japan

[2] Osaka Prefectural Inst Publ Hlth, Osaka 5370000, Japan

[3] Fumakilla Ltd, Hiroshima 7390000, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 05期

关键词：

insecticidal activity; antifungal activity; aminorhodanine; pathogenic fungus; rhodanine;

D O I：

10.1271/bbb.62.1025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminorhodanine (1) showed strong insecticidal activity against Culex pipiens pallens and Musca domestica, with respective LD50 values of 0.21 mu g/insect and 0.87 mu g/insect. Compound 1 had antifungal activity against Aspergillus niger ATCC-16404, Trichophyton mentagrophytes IFO-32412, Candida albicans ATCC-10231, Hansenula anomala OPS-308 and Penicillium expansum IFO-8800. In particular, 1 had potent antifungal activity against Aspergillus niger ATCC-16404, its minimal inhibitory concentration (MIC) being 6.25 mu g/ml. Both activities of 1 were much higher than those of rhodanine (4), suggesting that the introduction of an amino group into N-3 of 4 plays an important role in the biological activity of rhodanine-related compounds. On the other hand, N-acetylaminorhodanine (2) and N-benzoylaminorhodanine (3) did not show either activity, suggesting that the free amino group at N-3 of 1 is closely related to the inhibitory activity of rhodanine derivatives.

引用

页码：1025 / 1027

页数：3

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