Genetics of Alzheimer Disease

被引：629

作者：

Bekris, Lynn M. ^{[2
]}

Yu, Chang-En ^{[2
]}

Bird, Thomas D. ^{[3
]}

Tsuang, Debby W. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Med, Seattle, WA 98108 USA

[3] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA

来源：

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2010年 / 23卷 / 04期

关键词：

Alzheimer disease; genetics; neurodegeneration; AMYLOID-PRECURSOR-PROTEIN; APOLIPOPROTEIN-E GENOTYPE; GAMMA-SECRETASE; BETA-PROTEIN; TRANSGENIC MICE; MESSENGER-RNA; EPSILON-4; ALLELE; E POLYMORPHISM; A-BETA; NEUROFIBRILLARY TANGLES;

D O I：

10.1177/0891988710383571

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOE epsilon 4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.

引用

页码：213 / 227

页数：15

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