Genetics of Alzheimer Disease

被引：629

作者：

Bekris, Lynn M. ^{[2
]}

Yu, Chang-En ^{[2
]}

Bird, Thomas D. ^{[3
]}

Tsuang, Debby W. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98108 USA

[2] Univ Washington, Sch Med, Dept Med, Seattle, WA 98108 USA

[3] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA USA

来源：

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY | 2010年 / 23卷 / 04期

关键词：

Alzheimer disease; genetics; neurodegeneration; AMYLOID-PRECURSOR-PROTEIN; APOLIPOPROTEIN-E GENOTYPE; GAMMA-SECRETASE; BETA-PROTEIN; TRANSGENIC MICE; MESSENGER-RNA; EPSILON-4; ALLELE; E POLYMORPHISM; A-BETA; NEUROFIBRILLARY TANGLES;

D O I：

10.1177/0891988710383571

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the elderly individuals. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioral disturbances. Three causative genes have been associated with autosomal dominant familial AD (APP, PSEN1, and PSEN2) and 1 genetic risk factor (APOE epsilon 4 allele). Identification of these genes has led to a number of animal models that have been useful to study the pathogenesis underlying AD. In this article, we provide an overview of the clinical and genetic features of AD.

引用

页码：213 / 227

页数：15

共 179 条

[21] BACE1 is the major β-secretase for generation of Aβ peptides by neurons [J].

Cai, HB ;

Wang, YS ;

McCarthy, D ;

Wen, HJ ;

Borchelt, DR ;

Price, DL ;

Wong, PC .

NATURE NEUROSCIENCE, 2001, 4 (03) :233-234

[22] Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum [J].

Campion, D ;

Dumanchin, C ;

Hannequin, D ;

Dubois, B ;

Belliard, S ;

Puel, M ;

Thomas-Anterion, C ;

Michon, A ;

Martin, C ;

Charbonnier, F ;

Raux, G ;

Camuzat, A ;

Penet, C ;

Mesnage, V ;

Martinez, M ;

Clerget-Darpoux, F ;

Brice, A ;

Frebourg, T .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (03) :664-670

[23] Alzheimer's disease and cholesterol: The fat connection [J].

Canevari, Laura ;

Clark, John B. .

NEUROCHEMICAL RESEARCH, 2007, 32 (4-5) :739-750

[24]

Chai Chen K, 2007, Am J Alzheimers Dis Other Demen, V22, P37, DOI 10.1177/1533317506295655

[25] Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease [J].

Chauhan, NB .

JOURNAL OF LIPID RESEARCH, 2003, 44 (11) :2019-2029

[26] Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice [J].

Citron, M ;

Westaway, D ;

Xia, WM ;

Carlson, G ;

Diehl, T ;

Levesque, G ;

JohnsonWood, K ;

Lee, M ;

Seubert, P ;

Davis, A ;

Kholodenko, D ;

Motter, R ;

Sherrington, R ;

Perry, B ;

Yao, H ;

Strome, R ;

Lieberburg, I ;

Rommens, J ;

Kim, S ;

Schenk, D ;

Fraser, P ;

Hyslop, PS ;

Selkoe, DJ .

NATURE MEDICINE, 1997, 3 (01) :67-72

[27] A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease [J].

Coon, Keith D. ;

Myers, Amanda J. ;

Craig, David W. ;

Webster, Jennifer A. ;

Pearson, John V. ;

Lince, Diane Hu ;

Zismann, Victoria L. ;

Beach, Thomas G. ;

Leung, Doris ;

Bryden, Leslie ;

Halperin, Rebecca F. ;

Marlowe, Lauren ;

Kaleem, Mona ;

Walker, Douglas G. ;

Ravid, Rivka ;

Heward, Christopher B. ;

Rogers, Joseph ;

Papassotiropoulos, Andreas ;

Reiman, Eric M. ;

Hardy, John ;

Stephan, Dietrich A. .

JOURNAL OF CLINICAL PSYCHIATRY, 2007, 68 (04) :613-618

[28] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[29] Genetics - Once shunned, test for Alzheimer's risk headed to market [J].

Couzin, Jennifer .

SCIENCE, 2008, 319 (5866) :1022-1023

[30] Molecular genetics of Alzheimer's disease [J].

Cruts, M ;

Van Broeckhoven, C .

ANNALS OF MEDICINE, 1998, 30 (06) :560-565

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