Inhibitors of membrane receptors involved with leukocute extravasation

被引：16

作者：

Bendas, G ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmaceut Chem, Dept Pharm, D-53121 Bonn, Germany

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 06期

关键词：

adhesion molecules; autoimmune disease; endothelium; inflammation; integrins; leukocytes; selectins;

D O I：

10.2174/1389557054023279

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies, to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.

引用

页码：575 / 584

页数：10

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