Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils

被引：59

作者：

Mandell, GL ^{[1
]}

Coleman, E ^{[1
]}

机构：

[1] Univ Virginia, Hlth Syst, Div Infect Dis, Charlottesville, VA 22908 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1794-1798.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymorphonuclear neutrophils (PMN) are attracted to sites of infection. They have the potential to deliver antimicrobial agents to these sites if the agents enter the cells and do not alter migration. Penicillin G did not enter cells and was not transported by PMN, We found that azithromycin, ciprofloxacin, levofloxacin, moxifloxacin, and telithromycin were concentrated in PMN and transported toward a chemoattractant. These antimicrobial agents were released from the PMN and inhibited the growth of bacteria on test plates.

引用

页码：1794 / 1798

页数：5

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