The biology of CD45 and its use as a therapeutic target

被引：53

作者：

Dahlke, MH

Larsen, SR

Rasko, JEJ

Schlitt, HJ

机构：

[1] Univ Regensburg, Chirurg Klin & Poliklin, D-93053 Regensburg, Germany

[2] Centenary Inst Canc Med & Cell Biol, Sydney, NSW, Australia

[3] Univ Sydney, Sydney, NSW 2006, Australia

[4] Royal Prince Alfred Hosp, Dept Hepatobiliary Surg, Sydney, NSW, Australia

[5] Royal Prince Alfred Hosp, Sydney Canc Ctr, Sydney, NSW, Australia

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 02期

关键词：

CD45; tolerance; antibody mediated therapy; hemopoiesis;

D O I：

10.1080/1042819031000151932

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All mature hemopoietic lineage cells, with exclusion of platelets and mature erythrocytes, share the surface expression of a transmembrane phosphatase, the CD45 molecule. It is also present on hemopoietic stem cells and most leukemic clones and therefore presents as an appropriate target for immunotherapy with anti-CD45 antibodies. This short review details the biology of CD45 and its recent targeting for both treatment of malignant disorders and tolerance induction. In particular, the question of potential stem cell depletion for induction of central tolerance or depletion of malignant hemopoietic cells is addressed. Mechanisms underlying the effects downstream of CD45 binding to the cell surface are discussed.

引用

收藏

页码：229 / 236

页数：8

相关论文

共 66 条

[1] The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function [J].

Alexander, DR .

SEMINARS IN IMMUNOLOGY, 2000, 12 (04) :349-359

[2] DIFFERENTIAL-EFFECTS OF ANTI-CD45 MONOCLONAL-ANTIBODY ON HUMAN B-CELL PROLIFERATION - A MONOCLONAL-ANTIBODY RECOGNIZING A NEURAMINIDASE-SENSITIVE EPITOPE OF THE T200 MOLECULE ENHANCES ANTI-IMMUNOGLOBULIN-INDUCED PROLIFERATION [J].

ALSINET, E ;

INGLESESTEVE, J ;

VILELLA, R ;

LOZANO, F ;

MILA, J ;

ROJO, I ;

MARTORELL, J ;

VIVES, J ;

GAYA, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (12) :2801-2804

[3] The role of CD45 and CD45-associated molecules in T cell activation [J].

Altin, JG ;

Sloan, EK .

IMMUNOLOGY AND CELL BIOLOGY, 1997, 75 (05) :430-445

[4] CD45 and Src-family kinases: and now for something completely different [J].

Ashwell, JD ;

D'Oro, U .

IMMUNOLOGY TODAY, 1999, 20 (09) :412-416

[5] PTPRC (CD45) is not associated with the development of multiple sclerosis in US patients [J].

Barcellos, LF ;

Caillier, S ;

Dragone, L ;

Elder, M ;

Vittinghoff, E ;

Bucher, P ;

Lincoln, RR ;

Pericak-Vance, M ;

Haines, JL ;

Weiss, A ;

Hauser, SL ;

Oksenberg, JR .

NATURE GENETICS, 2001, 29 (01) :23-24

[6] Antibody-mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy [J].

Basadonna, GP ;

Auersvald, L ;

Khuong, CQ ;

Zheng, XX ;

Kashio, N ;

Zekzer, D ;

Minozzo, M ;

Qian, HY ;

Visser, L ;

Diepstra, A ;

Lazarovits, AI ;

Poppema, S ;

Strom, TB ;

Rothstein, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (07) :3821-3826

[7]

Beverley P C, 1992, Semin Immunol, V4, P35

[8] FUNCTIONAL SUBSETS OF T-CELLS DEFINED BY ISOFORMS OF CD45 [J].

BEVERLEY, PCL ;

DASER, A ;

MICHIE, CA ;

WALLACE, DL .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (01) :184-187

[9] Human B cells express a CD45 isoform that is siniflar to murine B220 and is downregulated with acquisition of the memory B-CeH marker CD27 [J].

Bleesing, JJH ;

Fleisher, TA .

CYTOMETRY PART B-CLINICAL CYTOMETRY, 2003, 51B (01) :1-8

[10] SURFACE AND CYTOPLASMIC EXPRESSION OF CD45 ANTIGEN ISOFORMS IN NORMAL AND MALIGNANT MYELOID CELL-DIFFERENTIATION [J].

CALDWELL, CW ;

PATTERSON, WP ;

TOALSON, BD ;

YESUS, YW .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1991, 95 (02) :180-187

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