The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

被引：98

作者：

Petersen, Trine P. ^{[1
,2
,3
]}

Polyzos, Anastasios ^{[1
,4
]}

O'Brien, Matthew ^{[1
]}

Ulven, Trond ^{[2
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Whiffen Lab, Cambridge CB2 1EW, England

[2] Univ So Denmark, Dept Chem & Phys, Odense, Denmark

[3] H Lundbeck & Co AS, Discovery Chem & DMPK, Valby, Denmark

[4] CSIRO, Clayton, Vic 3169, Australia

来源：

CHEMSUSCHEM | 2012年 / 5卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

alkynes; C?C coupling; flow chemistry; membranes; oxygen; GAS-LIQUID; BOND FORMATION; MASS-TRANSFER; OXIDATION; CARBON; CATALYSIS; REACTOR; AMINOCARBONYLATION; EFFICIENT; POLYYNES;

D O I：

10.1002/cssc.201100339

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The gas is always greener: A continuous flow Glaser-Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：274 / 277

页数：4

共 68 条

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