The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

被引：98

作者：

Petersen, Trine P. ^{[1
,2
,3
]}

Polyzos, Anastasios ^{[1
,4
]}

O'Brien, Matthew ^{[1
]}

Ulven, Trond ^{[2
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Whiffen Lab, Cambridge CB2 1EW, England

[2] Univ So Denmark, Dept Chem & Phys, Odense, Denmark

[3] H Lundbeck & Co AS, Discovery Chem & DMPK, Valby, Denmark

[4] CSIRO, Clayton, Vic 3169, Australia

来源：

CHEMSUSCHEM | 2012年 / 5卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

alkynes; C?C coupling; flow chemistry; membranes; oxygen; GAS-LIQUID; BOND FORMATION; MASS-TRANSFER; OXIDATION; CARBON; CATALYSIS; REACTOR; AMINOCARBONYLATION; EFFICIENT; POLYYNES;

D O I：

10.1002/cssc.201100339

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The gas is always greener: A continuous flow Glaser-Hay coupling reaction system, mediated by molecular oxygen, is developed based on a tube-in-tube gas/liquid reactor/injector. The system uses a semi-permeable Teflon AF-2400 membrane to effect rapid gas/liquid contact in flow, affording homogeneous solutions of oxygen. Measurements of out-gassing downstream of the back-pressure regulator indicate the onset of saturation is reached after about 16 seconds. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：274 / 277

页数：4

相关论文

共 68 条

[31] Transition-Metal-Catalyzed Oxidative Heck Reactions [J].

Karimi, Babak ;

Behzadnia, Hesam ;

Elhamifar, Dawood ;

Akhavan, Pari Fadavi ;

Esfahani, Farhad Kabiri ;

Zamani, Asghar .

SYNTHESIS-STUTTGART, 2010, (09) :1399-1427

[32] A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions [J].

Kelly, Christopher B. ;

Lee, Christopher ;

Mercadante, Michael A. ;

Leadbeater, Nicholas E. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (03) :717-720

[33] A microfluidic device for conducting gas-liquid-solid hydrogenation reactions [J].

Kobayashi, J ;

Mori, Y ;

Okamoto, K ;

Akiyama, R ;

Ueno, M ;

Kitamori, T ;

Kobayashi, S .

SCIENCE, 2004, 304 (5675) :1305-1308

[34]

Liang HR, 2011, CHINESE J ORG CHEM, V31, P586

[35] Asymmetric reactions in continuous flow [J].

Mak, Xiao Yin ;

Laurino, Paola ;

Seeberger, Peter H. .

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2009, 5

[36] Mass transfer coefficients in mechanically agitated gas-liquid contactors [J].

Markopoulos, Joannis ;

Christofi, Chrystalla ;

Katsinaris, Ioannis .

CHEMICAL ENGINEERING & TECHNOLOGY, 2007, 30 (07) :829-834

[37] Palladium(II)-Catalyzed Alkene Functionalization via Nucleopalladation: Stereochemical Pathways and Enantioselective Catalytic Applications [J].

McDonald, Richard I. ;

Liu, Guosheng ;

Stahl, Shannon S. .

CHEMICAL REVIEWS, 2011, 111 (04) :2981-3019

[38] A Microfluidic Approach to the Rapid Screening of Palladium-Catalysed Aminocarbonylation Reactions [J].

Miller, Philip W. ;

Jennings, Lucy E. ;

deMello, Andrew J. ;

Gee, Antony D. ;

Long, Nicholas J. ;

Vilar, Ramon .

ADVANCED SYNTHESIS & CATALYSIS, 2009, 351 (18) :3260-3268

[39] Accelerating reactions with microreactors at elevated temperatures and pressures: Profiling aminocarbonylation reactions [J].

Murphy, Edward R. ;

Martinelli, Joseph R. ;

Zaborenko, Nikolay ;

Buchwald, Stephen L. ;

Jensen, Klavs F. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (10) :1734-1737

[40]

Murphy EdwardR., 2007, ANGEW CHEM INT EDIT, V119, P1764

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