A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions

被引：31

作者：

Kelly, Christopher B. ^{[1
]}

Lee, Christopher ^{[1
]}

Mercadante, Michael A. ^{[1
]}

Leadbeater, Nicholas E. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2011年 / 15卷 / 03期

基金：

美国国家科学基金会;

关键词：

PRESSURIZED REACTION VESSELS; GASEOUS CARBON-MONOXIDE; ARYL IODIDES; SCALE-UP; REACTOR; CARBONYLATION; HYDROGENATION; MICROREACTORS; AMINOCARBONYLATION; REMOVAL;

D O I：

10.1021/op200037n

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Using a continuous-flow approach, it is possible to perform alkoxycarbonylation reactions of aryl iodides. Optimized reactor design allows for adequate mixing of gaseous and liquid reagents. Reactions are performed at rates of around 3 mL/min and at concentrations of 1 M, allowing for significant volumes to be processed per unit time. Palladium acetate (0.5 mol %) is used as the catalyst without the need for an additional ligand.

引用

页码：717 / 720

页数：4

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