Biosynthesis of violacein: a genuine intermediate, protoviolaceinic acid, produced by VioABDE, and insight into VioC function

被引：32

作者：

Shinoda, Kouhei

Hasegawa, Takuji

Sato, Hiroaki

Shinozaki, Masaaki

Kuramoto, Hirotomo

Takamiya, Yosuke

Sato, Tsutomu

Nikaidou, Naoki

Watanabe, Takeshi

Hoshino, Tsutomu ^{[1
]}

机构：

[1] Niigata Univ, Fac Agr, Dept Appl Biol Chem, Niigata 9502181, Japan

[2] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 40期

关键词：

D O I：

10.1039/b705358d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A biosynthetic intermediate of violacein produced by the mixed enzymes of VioABDE was elucidated to be 5-( 5- hydroxy1H- indol- 3- yl)- 3-( 1H- indol- 3- yl)- 1H- pyrrole- 2- carboxylic acid, named protoviolaceinic acid, indicating that VioC, responsible for the final biosynthetic step, works to oxygenate at the 2- position of the right side indole ring, and that the oxygenation reaction to form the central pyrrolidone core proceeds in a nonenzymatic fashion.

引用

页码：4140 / 4142

页数：3

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