Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

被引：45

作者：

Gao, PS

Mao, XQ

Kawai, M

Enomoto, T

Sasaki, S

Tanabe, O

Yoshimura, K

Shaldon, SR

Dake, Y

Kitano, H

Coull, P

Shirakawa, T ^{[1
]}

Hopkin, JM

机构：

[1] Churchill Hosp, Osler Chest Unit, Oxford OX3 7LJ, England

[2] Kyoto Prevent Med Ctr, Kyoto, Japan

[3] Japanese Red Cross Soc, Wakayama Med Ctr, Dept ORL, Wakayama, Japan

[4] Osaka Med Coll, Dept Pediat, Takatsuki, Osaka 569, Japan

[5] Jikei Univ, Sch Med, Inst DNA Med, Dept Gene Therapy, Tokyo, Japan

[6] Shiga Univ Med Sci, Dept ORL & Neck & Head Surg, Ohtsu, Shiga, Japan

[7] Churchill Hosp, Immunol Lab Unit, Oxford OX3 7LJ, England

来源：

HUMAN GENETICS | 1998年 / 103卷 / 01期

关键词：

D O I：

10.1007/s004390050783

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n = 275) and Japanese (n = 300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.

引用

页码：57 / 59

页数：3

共 19 条

[1] MATERNAL INHERITANCE OF ATOPIC IGE RESPONSIVENESS ON CHROMOSOME-11Q
COOKSON, WOCM
YOUNG, RP
SANDFORD, AJ
MOFFATT, MF
SHIRAKAWA, T
SHARP, PA
FAUX, JA
JULIER, C
LESOUEF, PN
NAKAMURA, Y
LATHROP, GM
HOPKIN, JM
[J]. LANCET, 1992, 340 (8816) : 381 - 384
[2] A sequence-ready high-resolution physical map of the best macular dystrophy gene region in 11q12-q13
Cooper, PR
Nowak, NJ
Higgins, MJ
Simpson, SA
Marquardt, A
Stoehr, H
Weber, BHF
Gerhard, DS
deJong, PJ
Shows, TB
[J]. GENOMICS, 1997, 41 (02) : 185 - 192
[3] HAY JG, 1995, AM J PHYSIOL, V268, P565
[4] WHOS TO BLAME FOR ASTHMA
HAYWARD, A
[J]. LANCET, 1995, 346 (8985): : 1243 - 1243
[5] HERWERDEN L, 1995, LANCET, V346, P1262
[6] A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): Associations with measures of atopy and bronchial hyper-responsiveness
Hill, MR
Cookson, WOCM
[J]. HUMAN MOLECULAR GENETICS, 1996, 5 (07) : 959 - 962
[7] LAING IA, 1998, IN PRESS J MED GENET
[8] Maternal inheritance of atopy at the Fc epsilon RI beta locus in Japanese sibs
Mao, XQ
Shirakawa, T
Sasaki, S
Enomoto, T
Morimoto, K
Hopkin, JM
[J]. HUMAN HEREDITY, 1997, 47 (03) : 178 - 180
[9] MAO XQ, 1998, IN PRESS CLIN GENET
[10] Marsh DG, 1997, NAT GENET, V15, P389

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