Proteasome: From structure to function

被引：21

作者：

Stock, D ^{[1
]}

Nederlof, PM ^{[1
]}

Seemuller, E ^{[1
]}

Baumeister, W ^{[1
]}

Huber, R ^{[1
]}

Lowe, J ^{[1
]}

机构：

[1] MAX PLANCK INST BIOCHEM, ABT STRUKT MOL BIOL, D-82152 MARTINSRIED, GERMANY

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1996年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0958-1669(96)80111-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily.

引用

页码：376 / 385

页数：10

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