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Adapters in lymphocyte signalling

被引：64
作者：
Leo, A
Schraven, B
机构：
[1] Heidelberg Univ, Inst Immunol, Blood Bank, D-69120 Heidelberg, Germany
[2] Heidelberg Univ, Inst Immunol, Immunomodulat Lab, D-69120 Heidelberg, Germany
[3] Univ Magdeburg, Inst Immunol, D-39120 Magdeburg, Germany
来源：
CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(00)00220-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Adapter proteins are well recognised as important molecular switches connecting immunoreceptors with intracellular signalling pathways. However, recent data suggest that homeostasis within the lymphatic system also depends on the coordinated activities of negative regulatory adapter proteins. These prevent activation of lymphocytes in the absence of externally applied signals and regulate termination/limitation of ongoing immune responses via different mechanisms.
引用
收藏
页码：307 / 316
页数：10
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