In search of a function for the TIS21/PC3/BTG1/TOB family

被引：214

作者：

Matsuda, S

Rouault, JP

Magaud, JP

Berthet, C

机构：

[1] Nagoya Univ, Sch Med, Dept Mol Pathogenesis, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Ctr Leon Berard, INSERM, U453, CNRS, F-69373 Lyon 08, France

来源：

FEBS LETTERS | 2001年 / 497卷 / 2-3期

关键词：

Btg1; Btg2; Btg3; Tob; Tob2; Pc3; Pc3b; Pc3k; Tis21; Fog3; amphitob; Ana; B9-10; B9-15; cell cycle; p53; Rb; anti-proliferative activity;

D O I：

10.1016/S0014-5793(01)02436-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Btg family of anti-proliferative gene products includes Pc3/Tis21/Btg2, Btg1, Tob, Tob2, Ana/Btg3, Pc3k and others. These proteins are characterized by similarities in their amino-terminal region: the Btg1 homology domain. However, the pleiotropic nature of these family proteins has been observed and no common physiological function among family members was suggested from the history of their identification. Recent progress in the search for Btg family functions has come from the analysis of cell regulation and of cell differentiation. It is now emerging that every member of this family has a potential to regulate cell growth. We would like to propose here to use a nomenclature APRO as a new term for the family. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B,V, All rights reserved.

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页码：67 / 72

页数：6

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