Epidermal stem cells

被引：28

作者：

Barthel, R ^{[1
]}

Aberdam, D ^{[1
]}

机构：

[1] Fac Med, INSERM, U634, F-06107 Nice, France

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2005年 / 19卷 / 04期

关键词：

cellular therapy; commitment; epidermal stem cell; gene therapy; mesenchymal niche; multipotentiality;

D O I：

10.1111/j.1468-3083.2005.01279.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The identification of adult epidermal stem cells that are capable of self-renewal and can reconstitute not only the epidermis but also the cutaneous appendages opens new perspectives for the treatment of a variety of human skin disorders including severe burns, cutaneous cancers, alopecia and acne. However, the implementation and improvement of these novel treatment strategies require a better understanding of the biology of stem cells, in particular regarding their isolation and the maintenance of their unique characteristics in culture. In this review, we summarize the main features of epidermal stem cells and we present the most recent advances in our understanding of the development and maintenance of these cells. In addition, we discuss some of the challenges and the potential clinical applications of epidermal stem cell technology.

引用

页码：405 / 413

页数：9

共 69 条

[1] Derivation of keratinocyte progenitor cells and skin formation from embryonic stem cells [J].