Long non-coding RNAs in nuclear bodies

被引：104

作者：

Ip, Joanna Y. ^{[1
,2
]}

Nakagawa, Shinichi ^{[1
]}

机构：

[1] RIKEN Adv Res Inst, RNA Biol Lab, Wako, Saitama, Japan

[2] Univ Toronto, Banting & Best Dept Med Res, Donnelly Ctr, Toronto, ON, Canada

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2012年 / 54卷 / 01期

关键词：

non-coding RNA; nuclear speckles; nuclear structure; paraspeckles; GENOMIC ANALYSIS; GENE-EXPRESSION; IDENTIFICATION; PARASPECKLES; ORGANIZATION; METASTASIS; RETENTION; REPEATS; MALAT-1; CELLS;

D O I：

10.1111/j.1440-169X.2011.01303.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

High-throughput analyses of mammalian transcriptomes have revealed that more than half of the transcripts produced by RNA polymerase II are non-protein-coding. One class of these non-coding transcripts is the long non-coding RNAs (lncRNAs), which are more than 200 nucleotides in length and are molecularly indistinguishable from other protein-coding mRNAs. Although the molecular functions of these lncRNAs have long remained unknown, emerging evidence implicates the functional involvement of lncRNAs in the regulation of gene expression through the modification of chromatin, maintenance of subnuclear structures, transport of specific mRNAs, and control of pre-mRNA splicing. Here, we discuss the functions of a distinct group of vertebrate-specific lncRNAs, NEAT1/MENe/beta/VINC, MALAT1/NEAT2, and Gomafu/RNCR2/MIAT, which accumulate abundantly within the nucleus as RNA components of specific nuclear bodies.

引用

页码：44 / 54

页数：11

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