Loss of tuberin from cerebral tissues with tuberous sclerosis and astrocytoma

被引：43

作者：

Mizuguchi, M

Kato, M

Yamanouchi, H

Ikeda, K

Takashima, S

机构：

[1] NCNP,NATL INST NEUROSCI,DEPT MENTAL RETARDAT & BIRTH DEFECT RES,TOKYO,JAPAN

[2] TOKYO INST PSYCHIAT,DEPT ULTRASTRUCT & HISTOCHEM,TOKYO,JAPAN

来源：

ANNALS OF NEUROLOGY | 1996年 / 40卷 / 06期

关键词：

D O I：

10.1002/ana.410400621

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the expression of tuberin, the TSC2 gene product, in cerebra with or without tuberous sclerosis. Tuberin was abundant in the gray matter of normal cerebra, but was undetectable in the subependymal astrocytomas from 3 patients with tuberous sclerosis. In 1 patient, cortical tubers and normally appearing cortical tissue also showed a marked loss of tuberin. These results indicate the critical role of tuberin in the neuropathology of tuberous sclerosis.

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页码：941 / 944

页数：4

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