Synthesis and antibacterial in vitro activity of novel analogues of nematophin

被引：17

作者：

Himmler, T ^{[1
]}

Pirro, F

Schmeer, N

机构：

[1] Bayer AG, Cent Res, D-51368 Leverkusen, Germany

[2] Bayer AG, Anim Hlth Res, D-51368 Leverkusen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(98)00358-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and in vitro antibacterial activity of new derivatives and analogues of nematophin are described. It was shown that the unsubstituted amide NH-group is essential for bioactivity. Alkyl- or aryl-substitution at the 1-position results in a distinct increase of antibacterial activity. Addition of protein (blood or serum) to the culture media reduces the inhibitory activity on bacteria. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2045 / 2050

页数：6

共 10 条

[1]

Brickner SJ, 1997, CHEM IND-LONDON, P131

[2]

COURVALIN P, 1997, ANTIBACTERIAL THERAP, P69

[3] N6-SUBSTITUTED ADENOSINE RECEPTOR AGONISTS - SYNTHESIS AND PHARMACOLOGICAL ACTIVITY AS POTENT ANTINOCICEPTIVE AGENTS [J].