Stability and commitment in T helper cell development

被引：71

作者：

Asnagli, H ^{[1
]}

Murphy, KM ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00210-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Specialized effector activities that are required to eliminate various pathogens involve cytokines produced by specialized CD4(+) T cells subsets, dogmatically termed Th1 and Th2 cells. Despite some oversimplifications, this paradigm is useful for organizing the complex pathways that control forward and backward movements along the road of T cell differentiation, Effective immune memory relies, in part, on the maintenance of the T helper phenotype. This review will address basic issues that relate to the maintenance or reversibility of Th1/Th2 states within the CD4(+) T cell lineage.

引用

页码：242 / 247

页数：6

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