Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii

被引：115

作者：

Lopez-Rojas, Rafael ^{[1
]}

Dominguez-Herrera, Juan ^{[1
]}

McConnell, Michael J. ^{[1
]}

Docobo-Perez, Fernando ^{[1
]}

Smani, Younes ^{[1
]}

Fernandez-Reyes, Maria ^{[2
]}

Rivas, Luis ^{[2
]}

Pachon, Jeronimo ^{[1
]}

机构：

[1] Univ Seville, Hosp Univ Virgen Rocio, Serv Enfermedades Infecciosas, Inst Biomed Sevilla,Consejo Super Invest Cient, Seville 41013, Spain

[2] CSIC, Ctr Invest Biol, Madrid, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 04期

关键词：

ANTIMICROBIAL PEPTIDE RESISTANCE; ENTERICA SEROVAR TYPHIMURIUM; PSEUDOMONAS-AERUGINOSA; PMRAB; INFECTIONS; SYSTEM; COST;

D O I：

10.1093/infdis/jiq086

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in vitro development of resistance to colistin. The colistin-resistant strain has lower affinity for colistin, reduced in vivo fitness (competition index, .016), and decreased virulence, both in terms of mortality (0% lethal dose, 6.9 vs 4.9 log colony-forming units) and survival in a mouse model of peritoneal sepsis. These results may explain the low incidence and dissemination of colistin resistance in A. baumannii in clinical settings.

引用

页码：545 / 548

页数：4

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