The Salmonella PmrAB regulon:: lipopolysaccharide modifications, antimicrobial peptide resistance and more

被引：250

作者：

Gunn, John S. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Microbial Interface Biol, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

来源：

TRENDS IN MICROBIOLOGY | 2008年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tim.2008.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbes are able to sense and respond to their environment primarily through the use of two-component regulatory systems. Many of these systems activate virulence-factor expression and are regulated by host-derived signals, having evolved to control gene expression at the key time and place for optimal establishment and maintenance of infection. Salmonella spp. are enteric pathogens that are able to survive both within host macrophages during systemic spread and killing by innate immune factors at intestinal mucosal surfaces. This review focuses on a key mechanism of pathogenesis that involves the PmrA-PmrB two-component system, which is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments.

引用

页码：284 / 290

页数：7

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