Molecular-weight-tagged glycopeptide library: Efficient construction and applications

被引：10

作者：

Ito, H

Kameyana, A

Sato, T

Kiyohara, K

Nakahara, Y

Narimatsu, H

机构：

[1] Natl Inst Adv Ind Sci & Technol, Res Ctr Glycosci, Tsukuba, Ibaraki 3058568, Japan

[2] Tokai Univ, Inst Glycotechnol, Dept Appl Biochem, Kanagawa 2591292, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 29期

关键词：

combinatorial chemistry; glycopeptides; high-throughput screening; mass spectrometry; transferases;

D O I：

10.1002/anie.200500802

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Generation of diversity: An oligosaccharide library can be constructed from glycopeptides by repeating incomplete glycosyltransferse (GTs) reactions in a single tube (see picture). Each product has a different molecular weight (MW). Therefore, the structure of each component in the library can be identified immediately by mass spectrometry alone. The differently colored shapes in the picture symbolize different glycosyl residues. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4547 / 4549

页数：3

共 25 条

[1] The bittersweet promise of glycobiology [J].