Plasmacytoid dendritic cells - virus experts of innate immunity

被引：158

作者：

Barchet, W ^{[1
]}

Cella, M ^{[1
]}

Colonna, M ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 04期

关键词：

virus; toll-like receptor; interferon; interferon-producing cell; plasmacytoid dendritic cell;

D O I：

10.1016/j.smim.2005.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Plasmacytoid dendritic cells (pDC) have emerged as a principal subset of dendritic cells in both human and mouse. PDC morphology, surface markers, their migration in vivo and the ability to rapidly produce large amounts of type 1 interferons (IFN-alpha/beta) in response to toll like receptor (TLR) triggering sets them apart from other dendritic cell subsets. This review highlights the features that make pDC uniquely able to sense and respond to viral infection. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：253 / 261

页数：9

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