Synthesis of C2-symmetrical bis-β-amino alcohols and their application in the enantioselective addition of diethylzinc to aldehydes

被引：28

作者：

Xu, QY

Wang, H

Pan, XF ^{[1
]}

Chan, ASC

Yang, TK

机构：

[1] Lanzhou Univ, Dept Chem, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[4] Natl Chunghsing Univ, Dept Chem, Taichung 40227, Taiwan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

关键词：

asymmetric addition; diethylzinc; C-2-symmetrical bis-beta-amino alcohols; aldehyde;

D O I：

10.1016/S0040-4039(01)01236-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-2-symmetrical bis-beta -amino alcohols 1-6 were prepared and especially attention is focused on bridges. which link the two beta -amino alcohol units. These ligands hake been applied as chiral catalysts in the asymmetric addition of diethylzinc to aldehydes. see-Alcohols have been obtained in good yields with up to 95.4%, enantiomeric excess. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：6171 / 6173

页数：3

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