Chiral phosphoric acid catalyzed enantioselective Friedel-Crafts alkylation of indoles with nitroalkenes:: Cooperative effect of 3 Å molecular sieves

被引：277

作者：

Itoh, Junji ^{[1
]}

Fuchibe, Kohei ^{[1
]}

Akiyama, Takahiko ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 21期

关键词：

asymmetric synthesis; Bronsted acids; enantioselectivity; Friedel-Crafts alkylation; indoles;

D O I：

10.1002/anie.200800770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Crafty catalysts: Friedel-Crafts alkylation of indoles with nitroalkenes proceeded in the presence of phosphoric acid 1 and 3 Å molecular sieves to give Friedel-Crafts adducts with excellent enantioselectivities (see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4016 / 4018

页数：3

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