A simple and practical resolution of 1,2:4,5-di-O-isopropylidene-myo-inositol

被引：21

作者：

Sureshan, KM ^{[1
]}

Yamasaki, T ^{[1
]}

Hayashi, M ^{[1
]}

Watanabe, Y ^{[1
]}

机构：

[1] Ehime Univ, Fac Engn, Dept Appl Chem, Matsuyama, Ehime 7908577, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 13期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0957-4166(03)00402-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient method for the resolution of 1,2:4,5-di-O-isopropylidene-myo-inositol has been developed. The diketal was converted to diastereomeric 3,6-di-O-mandelates by the reaction with (S)-O-acetylmandeloyl chloride. Both the diastereomers could be separated by sequential crystallization in multi-gram quantities. The enantiomers of the diol were obtained by removal of the chiral auxiliaries. Also the trans-isopropylidene was cleaved efficiently to obtain another pair of chiral diols. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1771 / 1774

页数：4

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